Science
A. the functional immune manifold
Context Matters in I&I
We probe responses in healthy and disease-associated backgrounds. Our discovery funnel combines fast functional imaging with deep molecular profiling.
Many Diseases, One Map
Some immune-mediated diseases share mechanisms, while others are unique. We probe mechanisms across multiple disease-relevant contexts at once.
Perturbation Screening to Ground AI
We learn about how disease works by pushing cell states with many parallel tool perturbations in the lab. AI predictions get grounded in real lab feedback.
Not Every Patient
Varied cell backgrounds are messy but necessary: therapies frequently don't work or have unacceptable side effects. Our platform can determine the difference in advance.
Smart Exploration
Each iteration guides the last, making a vast space of immune-relevant conditions accessible for the first time. Every validation round improves our predictions further.
The Functional Immune Manifold
Conditions, backgrounds, and cell context combine into a coherent picture of immune biology; with many downstream applications from positioning to development.
B. posters and publications
Quantifying ex vivo model realism for novel target discovery in inflammatory diseases
Poster, Target Validation in the Era of Genomics, Big Data and AI, Hinxton,
Functional Profiling of Rheumatoid Arthritis Reveals Disease-Specific Immunomodulatory Responses and Novel Therapeutic Targets
Poster, IMMUNOLOGY2026, Boston,
Functionally-Guided Multiomics Profiling of Human Systemic Inflammation Identifies Myeloid Therapeutic Targets
Poster, Keystone Symposia, Autoimmunity and Autoinflammation,
Decoding the functional and molecular niche of immune-mediated disease for iterative target discovery
Poster, CytoData 2025, Berlin,