Decoding Immune Dysfunction at Scale
Capturing real patient immune biology to power precision drug discovery, with unprecedented clinical realism.
A. in a nutshell
1. Many Diseases, Shared Biology
Immune-mediated diseases affect hundreds of millions of people. Many of them share mechanisms, so we map them together.
2. Functional Perturbation Mapping
Our labs measure how living immune cells from patients respond to hundreds of perturbations at once. We then train AI to guide the next round of experiments.
3. Preview Clinical Responses
Not all patients respond to the same therapies. Our experiments uncover what cell lines can't: for every mechanism, we learn who it will work for, and why.
4. Deep Validation
We validate target biology with orthogonal assays across diverse cohorts, so only the most promising therapies advance to patients.
5. Collaborate with us
We look for partners and research collaborators, not clients. Have a question we could answer together?
Learn more about our science1. Many Diseases, Shared Biology
Immune-mediated diseases affect hundreds of millions of people. Many of them share mechanisms, so we map them together.
2. Functional Perturbation Mapping
Our labs measure how living immune cells from patients respond to hundreds of perturbations at once. We then train AI to guide the next round of experiments.
3. Preview Clinical Responses
Not all patients respond to the same therapies. Our experiments uncover what cell lines can't: for every mechanism, we learn who it will work for, and why.
4. Deep Validation
We validate target biology with orthogonal assays across diverse cohorts, so only the most promising therapies advance to patients.
5. Collaborate with us
We look for partners and research collaborators, not clients. Have a question we could answer together?
Learn more about our scienceB. news and research
- Quantifying ex vivo model realism for novel target discovery in inflammatory diseasesResearch
- Graph Therapeutics Brings Total Funding to Over $10 Million to Advance Therapeutics Programs in Inflammation and ImmunologyNews
- Functional Profiling of Rheumatoid Arthritis Reveals Disease-Specific Immunomodulatory Responses and Novel Therapeutic TargetsResearch
- Functionally-Guided Multiomics Profiling of Human Systemic Inflammation Identifies Myeloid Therapeutic TargetsResearch
- Graph partners with Parse BiosciencesNews
- First data in RA - Cytodata 2025Research
- Data Foundations of Precision ImmunologyArticle
- Graph and BIIE announce strategic collaboration to in precision immunologyNews