Functional Profiling of Rheumatoid Arthritis Reveals Disease-Specific Immunomodulatory Responses and Novel Therapeutic Targets

Today’s RA therapies only slow disease. The next generation needs to cure it, and that first requires a comprehensive map of immune dysfunction, which is exactly what we’re working to build.

At IMMUNOLOGY2026, Graph’s co-founder and VP Immunology Christophe Boudesco presented the latest results from Graph’s Functional Immune Manifold (FIM): a platform that fuses functional perturbation of patient immune cells with multi-omics data to map immune dysfunction and uncover clinically positioned, therapeutically tractable biology in immune diseases.

The crux of our work is a generalized approach that merges large-scale functional profiling with sparse transcriptomic data. By combining functional responses with existing priors, we identify context-dependent, biomarker-stratified targets - the kind built for curative intent, not chronic management.

It’s a patient-first, clinically linked approach to I&I discovery. And we’re quickly advancing candidates into validation.

View our full poster here